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Summary Malignant solitary fibrous tumors are rare soft-tissue sarcomas. They are considered as low-grade malignancies, but may display metastatic potential in 20 % of the cases. In case of metastatic or locally advanced, unresectable disease, standard treatments, like anthracycline-based regimens, are poorly effective. Previous studies suggested that antiangiogenic drugs, such as sorafenib, could...
Sorafenib is a tyrosine kinase inhibitor prescribed primarily for the management of metastatic kidney cancer. It exhibits a good safety profile, but is the cause of a number of dermatological adverse effects. The most common and often the most troublesome is a specific hand-foot skin reaction (HFSR) affecting at least 30% of patients. It occurs predominantly on hyperkeratotic areas of the hands and...
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