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Her-2/neu overexpression is linked to poor prognosis and is a significant predictor of the response to trastuzumab (i.e., herceptin) therapy in breast cancer patients. Her-2/neu promotes angiogenesis with thrombospondin-1 (TSP-1) as a mediator in breast cancer development and progression. However, the clinical quantitative evaluation of Her-2/neu and specified localization of TSP-1 are currently lacking...
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