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Alzheimer disease (AD) is characterized by loss of memory and difficulty in learning which can be induced by dysfunction of ion channel genes. In this study, we apply the CTWC algorithm together with SPC method to microarray data measuring ion channel gene expression changes in AD tissue and the control tissue. The basic hypothesis here is that genes with similar expression patters are more likely...
Ion channels are important in many important physiological processes such as sensory transduction, action-potential generation and muscle contraction. Cardiomyopathy is a complex and multi-gene disease which hasn't been systematically analyzed by the perspective of ion channel genes. The aim of this study was to develop a bioinformatics approach to seek the transcriptional features leading to the...
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