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Introduction and objectives: Hypoxia-inducible factor 1α (HIF-1α) is a critical regulatory protein of cellular response to hypoxia and is closely related to the triggering of the angiogenic process. We examined the relationship between hypoxia and angiogenesis, as well as their prognostic impact in patients with urothelial bladder cancer.Methods: The immunohistochemical expression of HIF-1α was evaluated...
Objective: To elucidate the role of various bcl-2 family molecules in the regulation of apoptosis and the progression of urothelial cancer, in relation to standard prognosticators.Methods: Paraffin-embedded archival tissue from 103 N 0 M 0 consecutive patients with invasive bladder cancer (28 T1, 57 T2, 13 T3 and 5 T4) was immunostained for bcl-2, bax, bcl-X L , bcl-X S...
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