Search results for: C. Koehler

Items from 1 to 20 out of 95 results

article

Five‐year single‐center analysis of cytomegalovirus viremia in kidney transplant recipients and possible implication for novel prophylactic therapy approaches

Moritz Trappe, Patrick Affeldt, Franziska Grundmann, Martin Kann, more

Transplant Infectious Disease > 26 > 1 > n/a - n/a

Background Cytomegalovirus (CMV) infections are a common complication after kidney transplantation (KTx) and negatively affecting patient outcome. Valganciclovir (VGC) prophylaxis is often limited by drug‐induced side effects and dose reduction due to decline in kidney function. Method In the present study, episodes of CMV viremia in the first year after KTx in a cohort of 316 recipients were analyzed...

article

The Living Presidency: An Originalist Argument against Its Ever‐Expanding Powers. By Saikrishna Bangalore Prakash Cambridge, MA: Harvard University Press, 2020. 337 pp.

John C. Koehler

Presidential Studies Quarterly > 51 > 4 > 943 - 945

article

Quantitative validation of MRI mapping of cerebral venous oxygenation with direct blood sampling: A graded‐O₂ study in piglets

Dengrong Jiang, Raymond C. Koehler, Xiuyun Liu, Ewa Kulikowicz, more

Magnetic Resonance in Medicine > 86 > 3 > 1445 - 1453

Purpose To validate two neonatal cerebral venous oxygenation (Y_v) MRI techniques, T₂ relaxation under phase contrast (TRUPC) and accelerated TRUPC (aTRUPC) MRI, with oxygenation measured with direct blood sampling. Methods In vivo experiments were performed on seven healthy newborn piglets. For each piglet, a catheter was placed in the superior sagittal sinus to obtain venous blood samples for...

article

Fractional anisotropy from diffusion tensor imaging correlates with acute astrocyte and myelin swelling in neonatal swine models of excitotoxic and hypoxic‐ischemic brain injury

Jennifer K. Lee, Dapeng Liu, Dengrong Jiang, Ewa Kulikowicz, more

Journal of Comparative Neurology > 529 > 10 > 2750 - 2770

The specific cytopathology that causes abnormal fractional anisotropy (FA) and mean diffusivity (MD) from diffusion tensor imaging (DTI) after neonatal hypoxia‐ischemia (HI) is not completely understood. The panoply of cell types in the brain might contribute differentially to changes in DTI metrics. Because glia are the predominant cell type in brain, we hypothesized that changes in FA and MD would...

article

Targeting the mitochondrial permeability transition pore for neuroprotection in a piglet model of neonatal hypoxic‐ischemic encephalopathy

May W. Chen, Polan Santos, Ewa Kulikowicz, Raymond C. Koehler, more

Journal of Neuroscience Research > 99 > 6 > 1550 - 1564

Neonatal hypoxic‐ischemic encephalopathy (HIE) causes significant morbidity despite treatment with therapeutic hypothermia. Mitochondrial dysfunction may drive the mechanisms underlying neuronal cell death, thereby making mitochondria prime targets for neuroprotection. The mitochondrial permeability transition pore (mPTP) is one such target within mitochondria. In adult animal models, mPTP inhibition...

article

Attributable mortality of candidemia after introduction of echinocandins

Florian B. Cornely, Oliver A. Cornely, Jon Salmanton‐García, Felix C. Koehler, more

Mycoses > 63 > 12 > 1373 - 1381

Objectives Candidemia is among the most frequent nosocomial bloodstream infections. Landmark case‐control studies on amphotericin B and fluconazole estimated attributable mortality rates of 38% and 49%, respectively. After introduction of echinocandins, these may have decreased. Methods In a case‐control design, 100 consecutive, hospitalised patients with candidemia were enrolled at the University...

article

Mean Diffusivity in Striatum Correlates With Acute Neuronal Death but Not Lesser Neuronal Injury in a Pilot Study of Neonatal Piglets With Encephalopathy

Jennifer K. Lee, Dapeng Liu, Erika P. Raven, Dengrong Jiang, more

Journal of Magnetic Resonance Imaging > 52 > 4 > 1216 - 1226

Background Diffusion MRI is routinely used to evaluate brain injury in neonatal encephalopathy. Although abnormal mean diffusivity (MD) is often attributed to cytotoxic edema, the specific contribution from neuronal pathology is unclear. Purpose To determine whether MD from high‐resolution diffusion tensor imaging (DTI) can detect variable degrees of neuronal degeneration and pathology in piglets...

article

High‐sensitivity CEST mapping using a spatiotemporal correlation‐enhanced method

Lin Chen, Suyi Cao, Raymond C. Koehler, Peter C. M. Zijl, more

Magnetic Resonance in Medicine > 84 > 6 > 3342 - 3350

Purpose To obtain high‐sensitivity CEST maps by exploiting the spatiotemporal correlation between CEST images. Methods A postprocessing method accomplished by multilinear singular value decomposition (MLSVD) was used to enhance the CEST SNR by exploiting the correlation between the Z‐spectrum for each voxel and the low‐rank property of the overall CEST data. The performance of this method was evaluated...

article

The use of pressure‐controlled mechanical ventilation in a swine model of intraoperative pediatric cardiac arrest

Francis M. Lapid, Caitlin E. O'Brien, Sapna R. Kudchadkar, Jennifer K. Lee, more

Pediatric Anesthesia > 30 > 4 > 462 - 468

Background Current pediatric resuscitation guidelines suggest that resuscitators using an advanced airway deliver 8‐10 breaths per minute while carefully avoiding excessive ventilation. In the intraoperative setting, having a dedicated ventilation rescuer may be difficult because of limited personnel. Continuing pressure‐controlled mechanical ventilation during resuscitation for intraoperative cardiac...

article

Enhancing Protein A performance in mAb processing: A method to reduce and rapidly evaluate host cell DNA levels during primary clarification

Kenneth C. Koehler, Zona Jokondo, Janani Narayan, Alexei M. Voloshin, more

Biotechnology Progress > 35 > 6 > n/a - n/a

The use and impact of 3M™ Emphaze™ AEX Hybrid Purifier, a single‐use, fully synthetic chromatographic product, was explored to reduce host cell DNA (HC‐DNA) concentration during the primary clarification of a monoclonal antibody (mAb). An approximately 5‐log reduction in HC‐DNA was achieved at an Emphaze AEX Hybrid Purifier throughput of 200 L/m². The appreciable reduction in HC‐DNA achieved during...

article

ECMM CandiReg—A ready to use platform for outbreaks and epidemiological studies

Philipp Koehler, Maiken Cavling Arendrup, Sevtap Arikan‐Akdagli, Matteo Bassetti, more

Mycoses > 62 > 10 > 920 - 927

Background Recent outbreaks of Candida auris further exemplify that invasive Candida infections are a substantial threat to patients and healthcare systems. Even short treatment delays are associated with higher mortality rates. Epidemiological shifts towards more resistant Candida spp. require careful surveillance. Objectives Triggered by the emergence of C auris and by increasing antifungal resistance...

article

Baseline predictors influencing the prognosis of invasive aspergillosis in adults

Philipp Koehler, Jon Salmanton‐García, Stefanie K. Gräfe, Felix C. Koehler, more

Mycoses > 62 > 8 > 651 - 658

Invasive aspergillosis (IA) is a serious hazard to haematological and critical care patients. Impactful risk factors for developing IA have been characterised; however, systematic analysis of baseline prognostic factors for treatment course of IA is missing. To understand prognostic variables, we analysed original articles identifying baseline factors that predict treatment outcome in patients with...

article

Pathophysiological Insights into Spreading Depolarization in Severe Traumatic Brain Injury

Robert D. Stevens, Raymond C. Koehler

Neurocritical Care > 2019 > 30 > 3 > 569-571

This comment refers to the article available at https://doi.org/10.1007/s12028-019-00692-w .

article

Prostatic metastasis from intrahepatic cholangiocarcinoma

Georgi Tosev, Viktoria Schuetz, Joanne Nyarangi-Dix, Albrecht Stenzinger, more

Urology Case Reports > 2018 > 20 > C > 90-91

article

Refinement of embolic stroke model in rats: Effect of post-embolization anesthesia duration on arterial blood pressure, cerebral edema and mortality

Bryan T.C. Chuang, Xiaoguang Liu, Alexander J. Lundberg, Tommy J.K. Toung, more

Journal of Neuroscience Methods > 2018 > 307 > C > 8-13

Injection of a clot into the internal carotid artery is an experimental model of ischemic stroke that is considered to closely mimic embolic stroke in humans. In this model, the common carotid artery typically remains temporarily occluded to permit time for stabilization of the clot in the middle cerebral artery. However, the associated lengthening of the anesthesia duration could affect arterial...

article

The contribution of TRPV1 channel to 20-HETE—Aggravated ischemic neuronal injury

Xiaofan Zhang, Nagat El Demerdash, John R. Falck, Sailu Munnuri, more

Prostaglandins & Other Lipid Mediators > 2018 > 137 > C > 63-68

20-Hydroxyeicosatetraenoic acid (20-HETE), a cytochrome P450 (CYP) 4A/4F-derived metabolite of arachidonic acid, directly contributes to ischemic neuronal injury. However, little is known about mediators of 20-HETE neurotoxicity after ischemia. Here, we focus on the role of transient receptor potential cation channel subfamily V member 1 (TRPV1) in 20-HETE-induced neurotoxicity. Our results showed...

article

Candida‐reactive T cells for the diagnosis of invasive Candida infection of the lumbar vertebral spine

Felix C. Koehler, Oliver A. Cornely, Hilmar Wisplinghoff, De‐Hua Chang, more

Mycoses > 61 > 1 > 48 - 52

Invasive Candida infection is the fourth most common bloodstream infection. Blood cultures are the current gold standard diagnostic method, however, false negatives remain a clinical challenge. We developed a new technique measuring Candida‐reactive T cells as diagnostic read‐out for invasive Candida infection. In a pilot study, we followed the treatment course of a patient with an invasive Candida...

article

Inhibition of tPA-induced hemorrhagic transformation involves adenosine A2b receptor activation after cerebral ischemia

Qiang Li, Xiaoning Han, Xi Lan, Xiaohua Hong, more

Neurobiology of Disease > 2017 > 108 > C > 173-182

Tissue plasminogen activator (tPA) is administered after ischemic stroke to dissolve intravascular clots, but its use can lead to hemorrhagic transformation (HT). Therapeutic strategies to reduce hemorrhagic complications of tPA might be of benefit for stroke patients. Adenosine A2b receptor (A2bR) plays pivotal roles in regulating vascular protection in peripheral organs. This study explored whether...

article

MDS Post AA or MDS not Diagnosed

E. Krum, M. Faria Moss, E. Rodrigues, J. Koehler, more

Leukemia Research > 2017 > 55 > S1 > S135

article

Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen‐glucose deprivation

Yue Zhang, Gina Hong, Kin Sing Stephen Lee, Bruce D. Hammock, more

Journal of Neurochemistry > 140 > 5 > 814 - 825

Epoxyeicosatrienoic acids (EETs) are synthesized in astrocytes, and inhibitors of soluble epoxide hydrolase (sEH), which hydrolyzes EETs, reduce infarct volume in ischemic stroke. Astrocytes can release protective neurotrophic factors, such as vascular endothelial growth factor (VEGF). We found that addition of sEH inhibitors to rat cultured astrocytes immediately after oxygen‐glucose deprivation...

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INFONA - science communication portal

Search results for: C. Koehler

Five‐year single‐center analysis of cytomegalovirus viremia in kidney transplant recipients and possible implication for novel prophylactic therapy approaches

The Living Presidency: An Originalist Argument against Its Ever‐Expanding Powers. By Saikrishna Bangalore Prakash Cambridge, MA: Harvard University Press, 2020. 337 pp.

Quantitative validation of MRI mapping of cerebral venous oxygenation with direct blood sampling: A graded‐O₂ study in piglets

Fractional anisotropy from diffusion tensor imaging correlates with acute astrocyte and myelin swelling in neonatal swine models of excitotoxic and hypoxic‐ischemic brain injury

Targeting the mitochondrial permeability transition pore for neuroprotection in a piglet model of neonatal hypoxic‐ischemic encephalopathy

Attributable mortality of candidemia after introduction of echinocandins

Mean Diffusivity in Striatum Correlates With Acute Neuronal Death but Not Lesser Neuronal Injury in a Pilot Study of Neonatal Piglets With Encephalopathy

High‐sensitivity CEST mapping using a spatiotemporal correlation‐enhanced method

The use of pressure‐controlled mechanical ventilation in a swine model of intraoperative pediatric cardiac arrest

Enhancing Protein A performance in mAb processing: A method to reduce and rapidly evaluate host cell DNA levels during primary clarification

ECMM CandiReg—A ready to use platform for outbreaks and epidemiological studies

Baseline predictors influencing the prognosis of invasive aspergillosis in adults

Pathophysiological Insights into Spreading Depolarization in Severe Traumatic Brain Injury

Prostatic metastasis from intrahepatic cholangiocarcinoma

Refinement of embolic stroke model in rats: Effect of post-embolization anesthesia duration on arterial blood pressure, cerebral edema and mortality

The contribution of TRPV1 channel to 20-HETE—Aggravated ischemic neuronal injury

Candida‐reactive T cells for the diagnosis of invasive Candida infection of the lumbar vertebral spine

Inhibition of tPA-induced hemorrhagic transformation involves adenosine A2b receptor activation after cerebral ischemia

MDS Post AA or MDS not Diagnosed

Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen‐glucose deprivation

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