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The present study compares the pharmacokinetics of azithromycin in plasma, lung tissue, and bronchial washing after oral administration of 500mg (standard dose) versus 1000mg daily for 3 days. Samples were taken during surgery for lung resection at various time points up to 204h after the last drug dose, and azithromycin levels were analyzed by HPLC method. Azithromycin was widely distributed within...
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