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Résumé: Les carcinomes épidermoïdes des voies aérodigestives supérieures ont été considérés comme chimiorésistants jusqu’à la fin des années 70, les quelques agents actifs ne donnant que 10 à 30 % de réponses objectives en situation de récidive ou de métastase et une survie médiane de 6 mois. Les premiers essais de chimiothérapie d’induction associant cisplatine et 5Fu selon le protocole d’Al Sarraf...
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