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This study focused on the in vitro evaluation of skin perforation using a new microneedle device (Dermaroller ® ) with different needle lengths (150, 500 and 1500μm). The influence of the microneedle treatment on the morphology of the skin surface (studied by light and scanning electron microscopy), on the transepidermal water loss (TEWL) and on the penetration and permeation of hydrophilic...
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