Search results for: Wangjun Yan

Items from 1 to 20 out of 28 results

article

Prediction of nonsentinel lymph node metastasis in acral melanoma with positive sentinel lymph nodes

XinYi Lin, Wei Sun, Min Ren, Yu Xu, more

Journal of Surgical Oncology > 128 > 8 > 1407 - 1415

Background Metastasis in a nonsentinel lymph node (non‐SLN) is an unfavorable independent prognostic factor in cutaneous melanoma (CM). Recent data did suggest potential value of completion lymph node dissection (CLND) in CM patients with non‐SLN metastasis. Prediction of non‐SLN metastasis assists clinicians in deciding on adjuvant therapy without CLND. We analyzed risk factors and developed a prediction...

article

Optimal timing of re‐excision in synovial sarcoma patients: Immediate intervention versus waiting for local recurrence

Hongqiang Zhang, Wei Sun, Wending Huang, Wangjun Yan, more

Journal of Surgical Oncology > 128 > 8 > 1394 - 1406

Background To investigate the difference in efficacy of re‐excision in synovial sarcoma patients with and without residual tumor following unplanned excision, and to compare the prognostic outcomes of immediate re‐excision versus waiting for local recurrence. Method This study included synovial sarcoma patients who underwent re‐excision at our center between 2009 and 2019, categorized into groups...

article

Customized Multilevel 3D Printing Implant for Reconstructing Spine Tumor: A Retrospective Case Series Study in a Single Center

Zhengwang Sun, Mengchen Yin, Yueli Sun, Mo Cheng, more

Orthopaedic Surgery > 14 > 9 > 2016 - 2022

Objective To investigate the clinical efficacy and safety of 3D printed artificial vertebral body for patients who underwent multilevel total en bloc spondylectomy (TES) and analyze whether it could reduce the incidence of implant subsidence. Methods This is a retrospective study. From January 2017 to May 2018, eight consecutive cases with spine tumor undergoing multilevel TES were analyzed. All...

article

Freehand S2‐Alar‐Iliac Screw Placement Technique in Lumbosacral Spinal Tumors: A Preliminary Study

Wending Huang, Lun Xu, Weiluo Cai, Mo Cheng, more

Orthopaedic Surgery > 14 > 9 > 2195 - 2202

Objective S2‐alar‐iliac (S2AI) screw technique is widely used in spinal surgery, but it is rarely seen in the field of spinal tumors. The aim of the study is to report the preliminary outcomes of the freehand S2AI screw fixation after lumbosaral tumor resection. Methods The records of patients with lumbosacral tumor who underwent S2AI screw fixation between November 2016 to November 2020 at our...

article

Copper Clusters: An Effective Antibacterial for Eradicating Multidrug‐Resistant Bacterial Infection In Vitro and In Vivo

Xiangchun Zhang, Zhichao Zhang, Qingming Shu, Chao Xu, more

Advanced Functional Materials > 31 > 14 > n/a - n/a

Infections caused by multidrug‐resistant (MDR) bacteria pose a threat to human health worldwide, making new effective antibacterial agents urgently desired. To date, it is still a great challenge to develop new antibiotics for MDR bacteria with clear antibacterial mechanisms. Herein, a novel alternative antibacterial copper clusters (CuCs) molecule is precisely synthesized utilizing an artificially...

article

Prognostic analysis of surgically treated clear cell sarcoma: an analysis of a rare tumor from a single center

Shiqi Chen, Peng Luo, Lingge Yang, Biqiang Zheng, more

International Journal of Clinical Oncology > 2019 > 24 > 12 > 1605-1611

Background The objective of this retrospective study was to evaluate the prognostic value of various factors in clear cell sarcoma patients after radical surgery. Methods Forty-two clear cell sarcoma patients from August 2006 to March 2018 were included in the study. Curves of disease-free survival and overall survival were calculated using the Kaplan–Meier method, and univariate and multivariate...

article

TGF‐β induced PAR‐1 expression promotes tumor progression and osteoclast differentiation in giant cell tumor of bone

Ting Wang, Jian Jiao, Hao Zhang, Wang Zhou, more

International Journal of Cancer > 141 > 8 > 1630 - 1642

Although protease activated receptor‐1 (PAR‐1) has been confirmed as an oncogene in many cancers, the role of PAR‐1 in giant cell tumor (GCT) of bone has been rarely reported. The mechanism of PAR‐1 in tumor‐induced osteoclastogenesis still remains unclear. In the present study, we detected that PAR‐1 was significantly upregulated in GCT of bone compared to normal tissues, while TGF‐β was also overexpressed...

article

Treatment and outcome of metastatic paraganglioma of the spine

Qi Jia, Huabin Yin, Jian Yang, Zhipeng Wu, more

European Spine Journal > 2018 > 27 > 4 > 859-867

Background Spinal metastatic paraganglioma (MPG) is rare and only reported in individual case reports. The low incidence makes it difficult to define appropriate therapy and prognosis. Our study illustrated the largest series to discuss the possible treatment and outcomes of patients with spinal MPG. Methods A retrospective study of 15 patients with spinal MPG who were surgically treated between...

article

Surgical management and outcome of spinal alveolar soft part sarcoma (ASPA): a case series of five patients and literature review

Chenglong Zhao, Xin Gao, Jian Yang, Zhenxi Li, more

World Journal of Surgical Oncology > 2017 > 15 > 1 > 1-6

Background Alveolar soft part sarcoma (ASPS) is a rare entity of soft tissue malignancies with uncommon spinal involvements. Surgical management should be the best choice of cure. Methods Five patients with spinal ASPS were interviewed retrospectively, where data was collected. The relevant literatures were also systematically examined. Thereafter, patient and surgical data were obtained and pooled...

article

Adult-onset intradural spinal teratoma: report of 18 consecutive cases and outcomes in a single center

Wei Wan, Cheng Yang, Wangjun Yan, Tielong Liu, more

European Spine Journal > 2017 > 26 > 7 > 1917-1928

Study design Eighteen consecutive patients with adult-onset intradural spinal teratoma underwent surgical treatment in our center from 1998 to 2013. Background and purpose Teratoma is defined as a neoplasm composed of elements derived from three germ cell layers (ectoderm, endoderm and mesoderm). Intraspinal teratoma is extremely rare and accounts for 0.2–0.5% of all spinal cord tumors. Moreover,...

article

The surgical strategy for eosinophilic granuloma of the pediatric cervical spine complicated with neurologic deficit and/or spinal instability

Nanzhe Zhong, Wei Xu, Tong Meng, Xinghai Yang, more

World Journal of Surgical Oncology > 2016 > 14 > 1 > 1-8

Background Various therapeutic approaches have been proposed for the treatment of pediatric patients with eosinophilic granuloma (EG) of the cervical spine. Our aim was to discuss and present our experience with the individualized surgical intervention of pediatric cervical EG complicated with neurologic deficits and/or spinal instability. Methods We retrospectively analyzed the clinical data of...

article

HIF-1α activates hypoxia-induced PFKFB4 expression in human bladder cancer cells

Hao Zhang, Chengyin Lu, Meng Fang, Wangjun Yan, more

Biochemical and Biophysical Research Communications > 2016 > 476 > 3 > 146-152

PFKFB4 is reported to regulate glycolysis by synthesizing fructose-2, 6-bisphosphate (F2,6BP) and has proved to be associated with most malignancies. However, the underlying mechanism for increased PFKFB4 expression in bladder cancer remains unclear. The present study demonstrated that PFKFB4 was overexpressed in bladder cancer tissues. In addition, the expression of PFKFB4 elevated in bladder cancer...

article

Treatment options and prognosis for repeatedly recurrent giant cell tumor of the spine

Yifei Ma, Jialin Li, Jun Pan, Wangjun Yan, more

European Spine Journal > 2016 > 25 > 12 > 4033-4042

Background Giant cell tumor of the spine has high rate of postoperative recurrence. There are not much published studies on repeatedly recurrent GCTS (RRGCTS). Also, there are controversies as to the prognostic factors and treatment options for RRGCTS. Methods and materials A retrospective survival analysis between 2000 and September 2014 was performed on the 74 times of in-hospital treatment of...

article

TGF-β1-induced miR-202 mediates drug resistance by inhibiting apoptosis in human osteosarcoma

Zaijun Lin, Dianwen Song, Haifeng Wei, Xinghai Yang, more

Journal of Cancer Research and Clinical Oncology > 2016 > 142 > 1 > 239-246

Purpose A number of studies have demonstrated that microRNAs play a critical role in osteosarcoma progression, therapy and drug resistance. MicroRNA-202 has proven to be dysregulated in many human cancer studies. This study aimed to explore miR-202 contributions to drug resistance in osteosarcoma. Methods miR-202 expression was measured by real-time PCR in patient tissues, cell lines or cells treated...

article

P50-associated COX-2 extragenic RNA (PACER) overexpression promotes proliferation and metastasis of osteosarcoma cells by activating COX-2 gene

Ming Qian, Xinghai Yang, Zhenxi Li, Cong Jiang, more

Tumor Biology > 2016 > 37 > 3 > 3879-3886

P50-associated cyclooxygenase-2 (COX-2) extragenic RNA (PACER) is a novel long noncoding RNA that has been found to activate the COX-2 gene, which may function as an oncogene in osteosarcoma. However, the role of PACER and the relationship between PACER and COX-2 in osteosarcoma progression have been unknown until now. Here, we examined the expression levels of PACER in clinical tumor samples and...

article

XCR1 promotes cell growth and migration and is correlated with bone metastasis in non-small cell lung cancer

Ting Wang, Shuai Han, Zhipeng Wu, Zhitao Han, more

Biochemical and Biophysical Research Communications > 2015 > 464 > 2 > 635-641

Bone metastasis occurs in approximately 30–40% patients with advanced non-small cell lung cancer (NSCLC), but the mechanism underlying this bone metastasis remains poorly understood. The chemokine super family is believed to play an important role in tumor metastasis in lung cancer. The chemokine receptor XCR1 has been identified to promote cell proliferation and migration in oral cancer and ovarian...

article

Surgery for plasma cell neoplasia patients with spinal instability or neurological impairment caused by spinal lesions as the first clinical manifestation

Weiluo Cai, Wangjun Yan, Quan Huang, Wending Huang, more

European Spine Journal > 2015 > 24 > 8 > 1761-1767

Purpose Multiple myeloma (MM) and solitary plasmacytoma of bone (SPB) are two independent subtypes of plasma cell dyscrasias which often occur in spine. However, little is known about the surgical treatment of patients with spinal instability or neurological impairment caused by spinal lesions as the first clinical manifestation. The present study aimed to investigate the surgical outcome of these...

article

Surgery and survival outcomes of 30 patients with neurological deficit due to clear cell renal cell carcinoma spinal metastases

Shuai Han, Ting Wang, Dongjie Jiang, Yang Yu, more

European Spine Journal > 2015 > 24 > 8 > 1786-1791

Purpose The aim of this study was to provide some useful insights into the clinical and imaging presentations, treatment and prognostic factors in patients with neurological deficit caused by clear cell renal cell carcinoma (CCRCC) spinal metastases for the sake of designing individualized therapeutic plans for such patients. Methods A total of 30 patients with neurological deficit due...

article

Malignant peripheral nerve sheath tumor (MPNST) in the spine: a retrospective analysis of clinical and molecular prognostic factors

Ting Wang, Huabin Yin, Shuai Han, Xinhai Yang, more

Journal of Neuro-Oncology > 2015 > 122 > 2 > 349-355

Spinal malignant peripheral nerve sheath tumors (MPNSTs) are relatively rare. There is little information published in the literature regarding this subject. The aim of this retrospective study was to evaluate factors that may affect the outcomes of patients with spinal MPNSTs by reviewing 43 patients with spinal MPNST who were treated in our hospital between 2001 and 2012. Univariate and multivariate...

article

Treatment and outcome of malignant giant cell tumor in the spine

Huabin Yin, Mo Cheng, Bo Li, Binbin Li, more

Journal of Neuro-Oncology > 2015 > 124 > 2 > 275-281

Malignant giant cell tumor (MGCT) in the spine is extremely rare and there is little published information regarding this subject in the literature. We attempted to correlate different treatment options and outcomes over time. A retrospective study of patients with spinal MGCT who were surgically treated in our center between 2006 and 2012 was performed. Overall, three surgical management strategies,...

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INFONA - science communication portal

Search results for: Wangjun Yan

Prediction of nonsentinel lymph node metastasis in acral melanoma with positive sentinel lymph nodes

Optimal timing of re‐excision in synovial sarcoma patients: Immediate intervention versus waiting for local recurrence

Customized Multilevel 3D Printing Implant for Reconstructing Spine Tumor: A Retrospective Case Series Study in a Single Center

Freehand S2‐Alar‐Iliac Screw Placement Technique in Lumbosacral Spinal Tumors: A Preliminary Study

Copper Clusters: An Effective Antibacterial for Eradicating Multidrug‐Resistant Bacterial Infection In Vitro and In Vivo

Prognostic analysis of surgically treated clear cell sarcoma: an analysis of a rare tumor from a single center

TGF‐β induced PAR‐1 expression promotes tumor progression and osteoclast differentiation in giant cell tumor of bone

Treatment and outcome of metastatic paraganglioma of the spine

Surgical management and outcome of spinal alveolar soft part sarcoma (ASPA): a case series of five patients and literature review

Adult-onset intradural spinal teratoma: report of 18 consecutive cases and outcomes in a single center

The surgical strategy for eosinophilic granuloma of the pediatric cervical spine complicated with neurologic deficit and/or spinal instability

HIF-1α activates hypoxia-induced PFKFB4 expression in human bladder cancer cells

Treatment options and prognosis for repeatedly recurrent giant cell tumor of the spine

TGF-β1-induced miR-202 mediates drug resistance by inhibiting apoptosis in human osteosarcoma

P50-associated COX-2 extragenic RNA (PACER) overexpression promotes proliferation and metastasis of osteosarcoma cells by activating COX-2 gene

XCR1 promotes cell growth and migration and is correlated with bone metastasis in non-small cell lung cancer

Surgery for plasma cell neoplasia patients with spinal instability or neurological impairment caused by spinal lesions as the first clinical manifestation

Surgery and survival outcomes of 30 patients with neurological deficit due to clear cell renal cell carcinoma spinal metastases

Malignant peripheral nerve sheath tumor (MPNST) in the spine: a retrospective analysis of clinical and molecular prognostic factors

Treatment and outcome of malignant giant cell tumor in the spine

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