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Background and Aims
Nonalcoholic fatty liver disease (NAFLD) is characterized by accumulation of excessive triglycerides (TGs) in hepatocytes. Obesity is a major risk factor for developing fatty liver, although the intracellular molecular basis remains largely unclear. N6‐methyladenosine (m6A) RNA methylation is the most common internal modification in eukaryotic mRNA.
Approach and Results
In the...
Elevated thyroid‐stimulating hormone (TSH) and hypercholesterolemia commonly coexist, as typically seen in hypothyroidism, but there is no known mechanism directly linking the two. Here, we demonstrated that in liver cells, TSH promoted the expression of 3‐hydroxy‐3‐methyl‐glutaryl coenzyme A reductase (HMGCR), a rate‐limiting enzyme in cholesterol synthesis, by acting on the TSH receptor in hepatocyte...
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