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Patients with hepatocellular carcinoma frequently develop multiple anatomically separate liver tumours even at early stages of the disease, thus severely limiting the benefit of surgery. Hepatitis B virus is one of the most well recognised carcinogens causing hepatocellular carcinoma in man, and the integration of viral DNA into the host genome might sufficiently induce hepatocyte transformation....
Clinical observations suggest that the incidence of cough in Chinese patients taking angiotensin-converting enzyme (ACE) inhibitors is much higher than other racial groups. The aim of this study was to investigate whether SLCO1B1 genetic polymorphisms, previously reported to be important determinants of the inter-individual pharmacokinetic differences of enalapril, are associated with the enalapril-induced...
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