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Objective
In chronic lymphocytic leukemia, growing evidence has accumulated about long‐term outcomes of first‐line treatments. Our objective was to perform indirect comparisons across first‐line treatments.
Methods
We applied the Shiny method, an artificial intelligence technique that analyses Kaplan–Meier curves and reconstructs patient‐level data. Reconstructed patient data were then evaluated...
When multiple treatments are available, network meta-analysis can synthesize evidence and rank relative effectiveness. We applied this approach to current treatments for previously untreated chronic lymphocytic leukaemia. Data search was conducted in PubMed and websites of regulatory agencies (year 2000 through present time). Our analysis included randomized controlled trials assessing treatments...
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