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Abstract. To determine the role of cell proliferation and apoptosis in uterine leiomyoma growth, we studied protein expression of two major regulatory proteins of apoptosis Bcl-2 (anti-apoptotic) and Bax (pro-apoptotic) and two endogenous markers of cell replication proliferating cell nuclear antigen (PCNA) and Ki-67 in tumors and matched myometrium from premenopausal women. Conventional mitotic indices...
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