Search results for: K. Mller

Items from 1 to 20 out of 42 results

article

Horizontal gene transfer promoted evolution of the ability to propagate under anaerobic conditions in yeasts

Z. Gojkovi, W. Knecht, E. Zameitat, J. Warneboldt, more

Molecular Genetics and Genomics > 2004 > 271 > 4 > 387-393

The ability to propagate under anaerobic conditions is an essential and unique trait of brewers or bakers yeast (Saccharomyces cervisiae). To understand the evolution of facultative anaerobiosis we studied the dependence of de novo pyrimidine biosynthesis, more precisely the fourth enzymic activity catalysed by dihydroorotate dehydrogenase (DHODase), on the enzymes of the respiratory chain in several...

article

Vermeintliches Adenokarzinom des Samenstranges Aufklrung einer Gewebekontamination mittels Mikrosatellitenanalyse

M. Bodenbach, P. Adam, K. Kraft, H. K. Mller-Hermelink, more

Der Urologe > 2004 > 43 > 7 > 845-848

Maligne Tumoren des Samenstrangs sind eine Raritt und meist den Sarkomen zuzuordnen. Adenokarzinome werden extrem selten gefunden und sind fast immer Metastasen extragonadaler Malignome. Wir berichten ber einen symptomfreien 47-jhrigen Patienten, der in unsere Klinik zur weiteren Diagnostik eingewiesen wurde, nachdem im Rahmen einer auswrtigen Sterilisationsvasektomie ein Adenokarzinom des linken...

article

Isoliert extranodale Rosai-Dorfman-Erkrankung

A. M. Gassel, D. M. Lamskemper, J. Sold-Darseff, J. G. Mller, more

Der Pathologe > 2004 > 25 > 5 > 398-401

Ein 51-jhriger Patient aus Bulgarien stellte sich wegen eines extremen Exophthalmus des linken Auges und einer Weichteilschwellung der linken Schlfe in der Augenklinik vor. Bei der Diagnostik wurde ein groer unscharf begrenzter Tumor in der Orbita mit Einbruch in die Nasennebenhhlen gefunden. Das bei einer Biopsie und dem nachfolgenden Versuch der operativen Entfernung gewonnene Material bestand aus...

article

Different patterns of the L-histidine decarboxylase (HDC) gene expression in mice resistant and susceptible to experimental cutaneous leishmaniasis

Z. Ps, K. Mller, I. Novk, E. Buzs, more

Inflammation Research > 2004 > 53 > 1 > 38-43

Objective and design: In the present study the experimental murine Leishmania major (L. major) infection model was used to investigate the role of histamine biosynthesis in cutaneous leishmaniasis. Subjects, treatment and methods: A novel RNase Protection Assay (RPA) was developed and applied for the assessment of L-histidine decarboxylase (HDC) gene expression in organs of resistant C57BL/6 and susceptible...

article

Pyruvate decarboxylases from the petite-negative yeast Saccharomyces kluyveri

K. Mller, R. B. Langkjaer, J. Nielsen, J. Pikur, more

Molecular Genetics and Genomics > 2003 > 270 > 6 > 558-568

Saccharomyces kluyveri is a petite-negative yeast, which is less prone to form ethanol under aerobic conditions than is S. cerevisiae. The first reaction on the route from pyruvate to ethanol is catalysed by pyruvate decarboxylase, and the differences observed between S. kluyveri and S. cerevisiae with respect to ethanol formation under aerobic conditions could be caused by differences in the regulation...

article

Potential parameters for the detection of hGH doping

A. Kniess, E. Ziegler, J. Kratzsch, D. Thieme, more

Analytical and Bioanalytical Chemistry > 2003 > 376 > 5 > 696-700

The aim of our hGH application study with non-competitive athletes was the investigation of selected serum parameters from different processes affected by hGH. Fifteen athletes (age2133, mean24) were treated with 0.06IU hGH/kg BW per day or placebo (10hGH, 5placebo) respectively for 14days. Blood samples were taken prior to, during and until 10weeks after treatment. The concentrations of the following...

article

Pricing and reimbursement of drugs in Denmark

K. Mller Pedersen

The European Journal of Health Economics > 2003 > 4 > 1 > 60-65

The Danish health care system is decentralized and tax financed.Reimbursable drugs are financed by the national health insurance, which despite its official name, is a taxfunded system for paying for drugs,practicing physicians outside hospitals, dentists, etc. Most issues related to pricing and reimbursement of drugs are placed centrally, however, with the Danish Medicines Agency, and in contrast...

article

Hypermobilitt und chronischer Rckenschmerz

K. Mller, A. Kreutzfeldt, R. Schwesig, J. Mller-Pfeil, more

Manuelle Medizin > 2003 > 41 > 2 > 105-109

Hintergrund. Hypermobilitt wird zwar in der Literatur als ein Risikofaktor fr den chronischen Rckenschmerz diskutiert, wird allerdings in der rztlichen Praxis bislang noch weitestgehend unbercksichtigt gelassen. Ziel. Ziel der vorliegenden Arbeit ist es die Ausprgung ausgewhlter Parameter zur Charakterisierung des chronischen Rckenschmerzes bei hypermobilen im Vergleich zu normobilen Patienten zu...

article

PAF-Receptor in inflammatory versus non inflammatory human epidermis, cell cultures and embryonal cells

C. Bayerl, H. Brandt, M. Niemczyk, K. Mller-Decker, more

Inflammation Research > 2003 > 52 > 7 > 283-286

Abstract:Objective: PAF-R (platelet activating factor-receptor) has been found on human keratinocytes to bind PAF, a proinflammatory phospholipid. We aimed to study PAF-R in a range of dermal cell lines and in samples of normal and psoriatic human skin to learn about its further role in humans. Methods: PAF-R was labeled immunocytochemically, histochemically and additionally studied with western blotting...

article

Evidence for posttranscriptional regulation of the multi K homology domain protein vigilin by a small peptide encoded in the 5 leader sequence

J. Rohwedel, S. Kgler, T. Engebrecht, W. Purschke, more

Cellular and Molecular Life Sciences > 2003 > 60 > 8 > 1705-1715

Vigilin, a K homology (KH) protein has been found in all eukaryotic species studied. It has a unique structure of 1415 consecutively arranged KH domains which apparently mediate RNA-protein binding. Cloning and sequencing of the mouse vigilin cDNA confirmed that the amino acid sequences of vertebrate vigilins are highly conserved and contain conserved sequence motifs of nuclear import and export sequences...

article

The multi-KH protein vigilin associates with free and membrane-bound ribosomes

C. Kruse, D. Willkomm, J. Gebken, A. Schuh, more

Cellular and Molecular Life Sciences > 2003 > 60 > 10 > 2219-2227

The-multi-KH domain protein vigilin has been identified by ex vivo experiments as both a tRNA- and/or mRNA-binding protein. We show here that in vitro under conditions previously shown to allow tRNA binding, recombinant vigilin also binds to selected mRNA species and ribosomal RNA. An in vivo link of vigilin to mRNA and rRNA was elucidated by several approaches. (i) Coexpression/costimulation of vigilin...

article

Measurement of the production in proton-proton collisions with the COSY time-of-flight spectrometer

M. Abdel-Bary, S. Abdel-Samad, R. Bilger, K.-Th. Brinkmann, more

The European Physical Journal A > 2003 > 16 > 1 > 127-137

Abstract: The reaction pp pp was measured at excess energies of 15 and 41 MeV at an external target of the Jlich Cooler Synchrotron COSY with the time-of-flight spectrometer. About 25000 events were measured for the excess energy of 15 MeV and about 8000 for 41 MeV. Both protons of the process pp were detected with an acceptance of nearly 100% and the was reconstructed by the missing-mass technique...

article

Micromolded easy-assembly multi fiber connector: RibCon

U. Wallrabe, H. Dittrich, G. Friedsam, Th. Hanemann, more

Microsystem Technologies > 2002 > 8 > 2-3 > 83-87

AbstractThe fabrication and the design of a new fiber connector for up to 16 single- or multimode fibers are presented. The connector features the following essential advantages: low cost fabrication by micro injection molding, easy assembly due to elastic alignment structures made possible using LIGA technology and bonding by UV-curing adhesive, and a hermaphroditic connector design in order to avoid...

article

Injection molding of microstructured components from plastics, metals and ceramics

R. Ruprecht, T. Gietzelt, K. Mller, V. Piotter, more

Microsystem Technologies > 2002 > 8 > 4-5 > 351-358

AbstractMicro injection molding is presently on its way to become an established manufacturing process in commercialising Microsystem Technologies. Enhanced products from plastics for micro optical or medical applications are entering the market. New developments like the different kinds of injection molding for microstructured components from plastics, metals or ceramics will increase the material...

article

Aktuelle Mglichkeiten und Probleme der Dopingkontrolle

R. K. Mller, J. Groe, D. Thieme

Rechtsmedizin > 2001 > 11 > 6 > 284-297

Dopinganalytik kann als Teilgebiet der Toxikologischen Analytik angesehen werden, und die Beurteilung ihrer Ergebnisse sowie unter speziellen Umstnden (Todesflle oder Sptschden als vermutliche Folgen von Doping) der Korrelation von Ursache und Wirkung knnen forensisch-toxikologische und rechtsmedizinische Kompetenz erfordern. Trotz des sehr breiten Interesses auch der ffentlichkeit und einer in spektakulren...

article

The Composition-Dependent Presence of Free (Micellar) Alkylphospholipid in Liposomal Formulations of Octadecyl-1,1-dimethyl-piperidino-4-yl-phosphate Affects its Cytotoxic Activity in vitro

R. Zeisig, K. Mller, N. Maurer, D. Arndt, more

The Journal of Membrane Biology > 2001 > 182 > 1 > 61-69

Abstract. This study was performed to investigate the effect of cholesterol content, surface charge and sterical stabilization on the physico-chemical properties of liposomes prepared from the cancerostatic alkylphospholipid, octadecyl-1,1-dimethyl-piperidino-4-yl-phosphate (D21266), and their relationship to in vitro cytotoxicity. Stable incorporation of OPP into liposomes was found to be highly...

article

Mucosal humoral immune response to CagA shows a high prevalence in patients with gastric MALT-type lymphoma

B. Schmauer, M. Eck, A. Greiner, M. Kraus, more

Virchows Archiv > 2000 > 436 > 2 > 115-118

AbstractIn the pathogenesis of gastric mucosa-associated lymphoid tissue (MALT)-type lymphoma, CagA-positive Helicobacter pylori strains have been suspected of making a significant contribution. To investigate this hypothesis in more detail, the mucosal humoral immune response of 15 patients with gastric MALT-type lymphoma was examined in the tumor and in the tumor-free gastritis of the same patient...

article

Characterization of Wue-1, a novel monoclonal antibody that stimulates the growth of plasmacytoma cell lines

A. Greiner, M. Neumann, S. Stingl, S. Waink, more

Virchows Archiv > 2000 > 437 > 4 > 372-379

AbstractA new monoclonal antibody, Wue-1, which specifically recognizes normal and malignant plasma cells, is characterized. Biochemical studies showed that monoclonal antibodies (mAbs) recognize a protein of 94 kDa. Using triple-staining flow cytometry and double-labeling immunohistochemical techniques, two populations of plasma cells, i.e. lymphoplasmocytoid plasma cells located in the germinal...

article

Handlungsfhigkeit bei tdlich verlaufenen Intoxikationen mit Pflanzenschutzmitteln

R. Vock, H. Magerl, O. Lange, R. K. Mller

Rechtsmedizin > 1999 > 9 > 2 > 52-55

Zusammenfassung Die Einschtzung der Handlungsfhigkeit eines tdlich Vergifteten kann bei der Tatrekonstruktion sehr bedeutsam sein, insbesondere bei der Frage Selbst- oder Fremdbeibringung des Giftes. Klinische Publikationen gehen hierauf kaum ein. Deshalb wurden 20 gerichtliche Obduktionen der Institute fr Rechtsmedizin der Universitt Wrzburg und Leipzig sowie die dazugehrigen polizeilichen und staatsanwaltschaftlichen...

article

Handlungsfhigkeit bei tdlichen oralen Intoxikationen mit Cyan-Verbindungen

R. Vock, H. Magerl, O. Lange, P. Betz, more

Rechtsmedizin > 1999 > 9 > 2 > 56-61

Zusammenfassung Die Einschtzung der Handlungsfhigkeit eines tdlich Vergifteten kann bei der Tatrekonstruktion sehr bedeutsam sein, insbesondere bei der Frage Selbst- oder Fremdbeibringung des Giftes. Klinische Publikationen gehen hierauf kaum ein. Deshalb wurden 27 Flle tdlicher oraler Intoxikationen mit Cyan-Verbindungen der rechtsmedizinischen Institute Wrzburg, Hamburg, Mnchen, Berlin (FU), Tbingen,...

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Rechtsmedizin (5)
Cellular and Molecular Life Sciences (3)
Microsystem Technologies (3)
Virchows Archiv (3)
Analytical and Bioanalytical Chemistry (2)
Applied Microbiology and Biotechnology (2)
Der Pathologe (2)
European Radiology (2)
Inflammation Research (2)
Molecular Genetics and Genomics (2)
Rheumatology International (2)
Acta Neuropathologica (1)
Cell and Tissue Research (1)
Child's Nervous System (1)
Der Nervenarzt (1)
Der Urologe (1)
Diabetologia (1)
European Archives of Oto-Rhino-Laryngology (1)
International Journal of Colorectal Disease (1)
International Journal of Legal Medicine (1)
Manuelle Medizin (1)
Surgical Endoscopy (1)
The European Journal of Health Economics (1)
The European Physical Journal A (1)
The Journal of Membrane Biology (1)
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INFONA - science communication portal

Search results for: K. Mller

Horizontal gene transfer promoted evolution of the ability to propagate under anaerobic conditions in yeasts

Vermeintliches Adenokarzinom des Samenstranges Aufklrung einer Gewebekontamination mittels Mikrosatellitenanalyse

Isoliert extranodale Rosai-Dorfman-Erkrankung

Different patterns of the L-histidine decarboxylase (HDC) gene expression in mice resistant and susceptible to experimental cutaneous leishmaniasis

Pyruvate decarboxylases from the petite-negative yeast Saccharomyces kluyveri

Potential parameters for the detection of hGH doping

Pricing and reimbursement of drugs in Denmark

Hypermobilitt und chronischer Rckenschmerz

PAF-Receptor in inflammatory versus non inflammatory human epidermis, cell cultures and embryonal cells

Evidence for posttranscriptional regulation of the multi K homology domain protein vigilin by a small peptide encoded in the 5 leader sequence

The multi-KH protein vigilin associates with free and membrane-bound ribosomes

Measurement of the production in proton-proton collisions with the COSY time-of-flight spectrometer

Micromolded easy-assembly multi fiber connector: RibCon

Injection molding of microstructured components from plastics, metals and ceramics

Aktuelle Mglichkeiten und Probleme der Dopingkontrolle

The Composition-Dependent Presence of Free (Micellar) Alkylphospholipid in Liposomal Formulations of Octadecyl-1,1-dimethyl-piperidino-4-yl-phosphate Affects its Cytotoxic Activity in vitro

Mucosal humoral immune response to CagA shows a high prevalence in patients with gastric MALT-type lymphoma

Characterization of Wue-1, a novel monoclonal antibody that stimulates the growth of plasmacytoma cell lines

Handlungsfhigkeit bei tdlich verlaufenen Intoxikationen mit Pflanzenschutzmitteln

Handlungsfhigkeit bei tdlichen oralen Intoxikationen mit Cyan-Verbindungen

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