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The second messenger cyclic di‐AMP (c‐di‐AMP) is essential for growth of many bacteria because it controls osmolyte homeostasis. c‐di‐AMP can regulate the synthesis of potassium uptake systems in some bacteria and it also directly inhibits and activates potassium import and export systems, respectively. Therefore, c‐di‐AMP production and degradation have to be tightly regulated depending on the environmental...
Pyridoxal 5′‐phosphate (PLP), the most important form of vitamin B6 serves as a cofactor for many proteins. Two alternative pathways for de novo PLP biosynthesis are known: the short deoxy‐xylulose‐5‐phosphate (DXP)‐independent pathway, which is present in the Gram‐positive model bacterium Bacillus subtilis and the longer DXP‐dependent pathway, which has been intensively studied in the Gram‐negative...
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