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BACKGROUND
Proton therapy may reduce cognitive deficits after radiotherapy among brain tumor survivors, although current data are limited to retrospective comparisons between historical cohorts. The authors compared intelligence quotient scores within a case‐matched cohort of children with medulloblastoma treated with proton radiation (PRT) or photon radiation (XRT) over the same time period.
METHODS...
Background
Previous studies examining the time to initiate chemoradiation (CRT) after surgical resection of glioblastoma have been conflicting. To better define the effect that the timing of adjuvant treatment may have on outcomes, the authors examined patients within the National Cancer Database (NCDB) stratified by a validated prognostic classification system.
Methods
Patients with glioblastoma...
BACKGROUND
The addition of chemotherapy to adjuvant radiotherapy (chemotherapy and radiation therapy [CRT]) improves overall survival (OS) for patients with high‐risk grade 2 gliomas; however, the impact of chemotherapy alone (CA) is unknown. This study compares the OS of patients with high‐risk grade 2 gliomas treated with CA versus CRT.
METHODS
Patients with high‐risk grade 2 gliomas (subtotal...
BACKGROUNDThe purpose of the current study was to evaluate the impact of radiotherapy (RT) among women aged ≥ 70 years with T1‐2N0 estrogen receptor (ER)‐negative breast cancer using Surveillance, Epidemiology, and End Results (SEER)‐Medicare‐linked data.
METHODSThe study included 3432 women, 2850 of whom received and 582 of whom did not receive RT after breast‐conserving surgery. Outcomes were estimated...
BACKGROUNDProphylactic cranial irradiation (PCI) improves survival in patients with limited‐stage small cell lung cancer (SCLC) who have a complete response to chemotherapy and radiotherapy, yet to the best of the authors' knowledge, data specific to the elderly population are lacking.
METHODSUsing the Surveillance, Epidemiology, and End Results (SEER) database, the authors identified 1926 patients...
BACKGROUND:The use of radiation therapy (RT) “cone‐down” boost to reduce high‐dose treatment volumes according to tumor response to induction chemotherapy in patients with pediatric rhabdomyosarcoma (RMS) may reduce treatment morbidity, yet the impact on tumor control is unknown.
METHODS:Fifty‐five children, including 18 (33%) with parameningeal (PM) RMS and 37 (67%) with non‐PM RMS, who received...
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