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Background/Aims: Hepatic stellate cells represent the principal matrix-synthesising cells of damaged liver and are targets of a number of cytokines currently under investigation. The study analyses the effects of tumour necrosis factor-α and interferon-γ on proliferation, ''activation'' and protein synthesis of hepatic stellate cells.Methods: Primary cultures of hepatic stellate cells were exposed...
Background/Aims: Chronic bile duct obstruction in the rat leads to biliary cirrhosis and portal hypertension. Biliary decompression with Roux-en-Y choledocho-jejunostomy (RY) reverses most but not all of these changes. The aim of the present study was to determine whether hepatic stellate cells, as a main source of extracellular matrix proteins, participate in this process.Methods: Sprague-Dawley...
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