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Cyclooxygenase-2 (COX-2) has been implicated in a number of hepatic stellate cell (HSC) functions but its relationship to transforming growth factor-β1 (TGF-β1)-mediated fibrogenesis is unknown. We assessed the impact of COX-2 inhibition and PGE 2 on the regulation of TGF-β1-stimulated matrix synthesis in an immortalized human HSC line, LX-1 and corroborated these findings in primary stellate...
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