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We examined whether dietary fish oil can prevent acute ethanol (alcohol)-induced fatty liver.Mice were fed safflower oil, fish oil, or safflower oil plus a PPARα activator on the day prior to ethanol administration. Oil red O staining, serum analysis, and RT-PCR were used to analyze ethanol-induced fatty liver.In mice fed safflower oil, ethanol increased liver TG 3-fold, with activation of SREBP-1c...
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