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Although nitric oxide (NO) was identified more than 150years ago and its effects were clinically tested in the form of nitroglycerine, it was not until the decades of 1970–1990 that it was described as a gaseous signal transducer. Since then, a canonical pathway linked to cyclic GMP (cGMP) as its quintessential effector has been established, but other modes of action have emerged and are now part...
Clarity about the nitric oxide (NO) concentrations existing physiologically is essential for developing a quantitative understanding of NO signalling, for performing experiments with NO that emulate reality, and for knowing whether or not NO concentrations become abnormal in disease states. A decade ago, a value of about 1μM seemed reasonable based on early electrode measurements and a provisional...
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