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Summary
Background
Activated coagulation factor IX (FIXa) consists of a γ‐carboxyglutamic acid domain, two epidermal growth factor‐like (EGF) domains, and a C‐terminal protease domain. Consensus sequence and biochemical data support the existence of a Na+‐site in the FIXa protease domain. However, soaking experiments or crystals grown in high concentration of ammonium sulfate did not reveal...
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