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Research in systems biology integrates experimental, theoretical, and modeling techniques to study and understand biological processes such as gene regulation. The genomic sequences for human and other model organisms such as yeast and bacteria are already established. The next major step is to discover functional roles of genes whose functions are not yet discovered and to investigate how genes interact...
This paper present the design and analysis of 8-bit Smith Waterman (SW) based DNA sequence alignment accelerator's core on ASIC design flow. The objective of the project is to construct and analyse the core module that can perform the Smith Waterman algorithm's operations, which are comparing, scoring and back tracing, using the technique used in on ASIC design flow. Nowadays, the DNA and protein...
The problem of protein structural family classification remains a core problem in computational biology, with application of this technology applicable to problems in drug discovery programs and hypothetical protein annotation. Many machine learning tools have been applied to this problem using static machine learning structures such as neural networks or support vector machines that are unable to...
The classification of protein sequences into families is an important tool in the annotation of structural and functional properties to newly discovered proteins. We present a classification system using pattern recognition techniques to create a numerical vector representation of a protein sequence and then classify the sequence into a number of given families. We introduce the use of fuzzy ARTMAP...
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