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To investigate the effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor on the tissue damage and fibrosis of obstructed ureters, 80 rats were studied.Atorvastatin, a HMG-CoA reductase inhibitor, was administered to 40 rats at the dose of 20mg/kg per day 1day before unilateral ligation of ureters and every day thereafter. The other rats served as controls. Eight rats from...
Nuclear factor (NF)-κB is a ubiquitous transcription factor that can be activated by multiple signals. To elucidate the role of NF-KB and the effects of NF-κB inhibitor on ureteric damages in obstructive uropathy, we conducted this study.The expressions of NF-κBp50, NF-κBp65, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), proliferation cell nuclear antigen (PCNA) and cell apoptosis were...
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