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Key points
During exercise, bradykinin (BK), a muscle metabolite in ischaemic muscles, exaggerates autonomic responses to activation of muscle afferent nerves in peripheral artery disease (PAD).
We examined whether BK inhibits activity of KV4 channels in muscle afferent neurons of PAD rats induced by femoral artery occlusion.
We demonstrated that: 1) femoral occlusion attenuates KV4 currents in...