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Low responsiveness to anti‐programmed death‐1/programmed death‐ligand 1 (anti‐PD‐1/PD‐L1) for solid tumors indicates the presence of other immunosuppressive pathways. Siglec15, a newly discovered immune checkpoint, has been reported to repress immune responses in the tumor microenvironment (TME) and regulate osteoclast differentiation. However, the role of Siglec15 in the treatment for bone metastasis...