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Matrix Stiffness Gradient
Humans possess different kinds of soft‐hard tissue interfaces, where the immunophenotype of mesenchymal stem cells (MSCs) can be efficiently modulated by the matrix stiffness gradient existing in these interfaces. In article number 2309676, Yufei Ma, Dandan Pei, Ang Li, Feng Xu, and co‐workers design a two layered hydrogel platform with high and low stiffness gradients, respectively,...
Soft‐hard tissue interfaces are widespread in the human body, where matrix stiffness gradient at the cellular scale is a typical biophysical cue that cells experience. However, most studies have focused on the large‐scale matrix stiffness gradient that affected cell fate. It is still necessary to elucidate the impact of cellular‐scale matrix stiffness gradient on cell behavior and function, such as...
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