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This study was designed to examine the impact of mitochondrial aldehyde dehydrogenase 2 (ALDH2) on transverse aorta constriction (TAC)-induced cardiac hypertrophy and related molecular mechanisms using an ALDH2 knockout (ALDH2−/−) murine model.Male wild-type and ALDH2−/− mice were subjected to TAC or sham operation (n=6–8 for each group). After two weeks, cardiac function was assessed by echocardiography...
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