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In the present work, we prepared memantine–pamoic acid (MEM–PAM) salt by counter ion exchange in the aqueous phase to reduce the water solubility of MEM hydrochloride (native form) to make it suitable for long acting injection. The ratio of MEM to PAM in salt formation was optimized to maximize the loading efficiency and complexation efficiency. The 2:1molar ratio of MEM to PAM salt form displayed...
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