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Background and Objective
Photodynamic therapy (PDT) has been widely used to treat malignant tumors. Our previous studies indicated that connexin (Cx) 32‐ and Cx26‐composed gap junctional intercellular communication (GJIC) could improve the phototoxicity of PDT. However, the role of heterotypic Cx32/Cx26‐formed GJIC in PDT phototoxicity is still unknown. Thus, the present study was aimed to investigate...
In spite of the promising initial treatment responses presented by photodynamic therapy (PDT), 5‐year recurrence rates remain high level. Therefore, improvement in the efficacy of PDT is needed. There are reports showing that connexin(Cx) 26‐composed gap junctional intercellular communication (GJIC) enhances the intercellular propagation of “death signal”, thereby increasing chemotherapeutic cytotoxicity...
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