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We wished to evaluate the efficiency of internal quality control procedures of a cohort study investigating human papilloma virus (HPV) infection as a key exposure factor in oesophageal cancer in Anyang, China. This was done by testing 2395 environmental/equipment swab and mock quality control samples from 14 loci on sample collection equipment for human β-globin and HPV DNA. Human β-globin was present...
The desirability function method is widely used for simultaneous optimization of several independent or uncorrelated responses. In practical applications, a second-order polynomial is usually employed to represent each response based on RSM. Then a functional form for the overall desirability will be reached. The so-obtained overall desirability function is usually nondifferentiable, highly nonlinear...
This paper discusses multi-response robust parameter optimization based on response surface models using desirability function method. When specifications of the output responses are given, the design region may be divided into several areas or spaces. Research shows that solution with highest desirability may not be robust. To achieve robust solution we should consider where the solution lying in...
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