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Background
In mast cells, induction of HSP70 expression during antigen stimulation has not been reported.
Methods
Mouse bone marrow‐derived mast cells (BMMC) were stimulated with IgE/Ag or HSP70. Induction of HSP70 expression and signaling protein phosphorylation were evaluated by immunoblotting.
Results
HSP70 expression is induced in BMMC at an early stage of IgE/Ag‐dependent stimulation, some...
BackgroundIgE/Ag‐stimulated mast cells release various pro‐allergic inflammatory mediators, including histamine, eicosanoids, and pro‐inflammatory cytokines. NecroX‐5, a cell permeable necrosis inhibitor, showed cytoprotective effects in both in vitro and in vivo models. However, the anti‐allergic effect of NecroX‐5 has not yet been investigated. The aims of this study were to evaluate the anti‐allergic...
BackgroundTryptophan metabolites have been suggested to play a role in immune modulation, wherein those have recently been shown to be endogenous ligands of aryl hydrocarbon receptor (AhR; a unique cellular chemical sensor). However, the involvement of tryptophan metabolites and AhR in modulating mast cell function remains to be fully defined. We therefore investigated that the functional impacts...
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