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One of the main challenges in treating opioid‐use disorders is relapse during abstinence, triggered by re‐exposure to drug‐associated cues. Previous studies have demonstrated that drug‐seeking in rats progressively increases over time during withdrawal (incubation of drug craving). Here, we used male rats and examined neural mechanisms underlying incubation of craving to oxycodone, a commonly abused...
Cue‐induced drug craving progressively increases after prolonged withdrawal from drug self‐administration in laboratory animals, a behavioral phenomenon termed ‘incubation of drug craving.’ Studies over the years have revealed several important neural mechanisms contributing to incubation of drug craving. In this mini‐review, we first discuss three excellent AddictionBiology publications on incubation...
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