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Sonosensibilisatoren Mei‐Rong Ke, Jian‐Dong Huang et al. berichten in ihrer Zuschrift (e202113506) über eine aggregationsverstärkte sonodynamische Aktivität (AESA). Der AESA‐Effekt könnte einen neuen Weg für die Entwicklung effizienter Sonosensibilisatoren eröffnen.
The clinical prospect of sonodynamic therapy (SDT) has not been fully realized due to the scarcity of efficient sonosensitizers. Herein, we designed phthalocyanine–artesunate conjugates (e.g. ZnPcT4A), which could generate up to ca. 10‐fold more reactive oxygen species (ROS) than the known sonosensitizer protoporphyrin IX. Meanwhile, an interesting and significant finding of aggregation‐enhanced sonodynamic...
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