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Using murine IgG subclass molecules (IgG1 or IgG2a) synthetically fused to HIV-1 or influenza test antigens, we explored the potential for IgG Fc scaffolds to augment immunogenicity. Each antigen (Ag) was grafted onto a hinge-Fc scaffold containing all critical residues necessary for interaction with effector cells, thus retaining effector functions of the native IgG subclass. We hypothesized that...
A number of studies have shown that the natural killer T cell (NKT) ligand α-galactosylceramide (α-GalCer) serves as an adjuvant for various vaccines, including viral vaccines, parasite vaccines and protein vaccines. In this report, we investigated the adjuvant activity of α-GalCer on HIV-1 DNA vaccines in mice. This is a first study to show that α-GalCer can enhance the immunogenicity of DNA vaccines,...
Intramuscular delivery of plasmid DNA encoding vaccine antigens induces systemic immune responses in small animals but is less effective in inducing strong responses in larger animals species. We investigated if anatomic distribution of DNA could enhance responses to decreasing DNA doses. We show that anatomic distribution of low-dose DNA improves cell-mediated and humoral immune responses in mice...
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