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Recently, there has been a growing interest in developing Computer Aided Diagnostic (CAD) systems for improving the reliability and consistency of pathology test results. This paper describes a novel CAD system for the Anti-Nuclear Antibody (ANA) test via Indirect Immunofluorescence protocol on Human Epithelial Type 2 (HEp-2) cells. While prior works have primarily focused on classifying cell images...
We propose a quick and widely applicable approach for converting biometric identification match scores to probabilistic confidence scores, resulting in increased discrimination accuracy. This approach builds on a confidence scoring approach for Binomial distributions resulting from Hamming distances (commonly used in iris recognition). We derive a Gaussian confidence scoring approach that is three...
Indirect Immunofluorescence (IIF) on Human epithelial (HEp-2) cells test has been the golden standard for identifying the presence of Anti-Nuclear Antibodies (ANA) due to its high sensitivity and the large range of antigens that can be detected. Furthermore, IIF ANA test allows the positive sample strength (sample end point titre) to be reported. Despite its advantages, the IIF ANA test needs to be...
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