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One-carbon metabolism has been presumed to influence cancer pathogenesis. Cytosolic serine hydroxymethyltransferase (cSHMT) is a critical enzyme in one-carbon metabolism pathway. Until now, many studies have investigated the association between cSHMT (also named SHMT1) C1420T polymorphism and breast cancer risk. However, the results remained conflicting rather than conclusive. Literature search was...
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