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BACKGROUNDHistone deacetylase (HDAC) inhibitors are successful for treatment of advanced cutaneous T‐cell lymphoma but only show modest effect in solid tumors. Approaches for HDAC inhibitors to improve activity against solid tumors are necessary.
METHODSSulforhodamine B assay and flow cytometric analysis detected cell proliferation and cell‐cycle progression, respectively. Protein expression was...
BACKGROUNDChalcones are contained in fruits and vegetables, and have been suggested to display anticancer activities. In this study, the anticancer mechanism of WJ9708011 (a methoxychalcone derivative) was delineated in human prostate cancer cells.
METHODCell proliferation was examined by sulforhodamine B and clonogenic assays. Cell‐cycle progression and mitochondrial membrane potential (ΔΨm) were...
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