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Inhibition of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and excessive inflammation is the current task in the prevention and treatment of corona vireus disease 2019 (COVID‐19). Here, a dual‐function circular aptamer‐ASO chimera (circSApt‐NASO) is designed to suppress SARS‐CoV‐2 replication and inflammation. The chemically unmodified circSApt‐NASO exhibits high serum stability...
The epigenetic dysregulation and hypoxia are two important factors that drive tumor malignancy, and N6‐methyladenosine (m6A) in mRNA is involved in the regulation of gene expression. Herein, a nanocatalyst OsSx‐PEG (PEG = poly(ethylene glycol)) nanoparticles (NPs) as O2 modulator is developed to improve tumor hypoxia. OsSx‐PEG NPs can significantly downregulate genes involved in hypoxia pathway. Interestingly,...
MnO as anode materials has received particular interest owing to its high specific capacity, abundant resources, and low cost. However, serious problems related to the large volume change (>170%) during the lithiation/delithiation processes still results in poor rate capability and fast capacity decay. With homogenous crystals of MnO grown in the network of carbon nanofibers (CNF), binding effect...
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