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Inhibition of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and excessive inflammation is the current task in the prevention and treatment of corona vireus disease 2019 (COVID‐19). Here, a dual‐function circular aptamer‐ASO chimera (circSApt‐NASO) is designed to suppress SARS‐CoV‐2 replication and inflammation. The chemically unmodified circSApt‐NASO exhibits high serum stability...
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