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The endothelin-A receptor ligand Atrasentan (ABT-627) was radiolabeled by 11 C-methylaton of the desmethyl precursor in phenolate form. In mice, the highest uptake of [ 11 C]ABT-627 was in the liver, kidneys and lungs. No significant binding was observed in mouse brain or heart. PET studies in a baboon, however, showed accumulation in the myocardium and lungs with a tissue/blood equilibrium...
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