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Morphine-6β-glucuronide (M6G) is well known as a potent active metabolite in humans. To clarify concentration–antinociceptive effect relationships for morphine and M6G, we evaluated comparatively the pharmacokinetics and antinociceptive effects of morphine and M6G. The spinal CSF concentration and antinociception were simultaneously measured by using the combination of a microdialysis method and the...
Colominic acid (CA), produced by Escherichia coli K1, is a polymer of sialic acid linked through α (2→8) glycosidic linkages. Although there are several studies on the biological activities of chemically sulfated CA, the activity of CA has been incompletely understood. In the present study, we investigated the effects of CA, prepared as an α2,8-linked homopolymer of N-acetylneuraminic acid, on the...
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