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RNA-Seq, a deep sequencing technique, promises to be a potential successor to microarraysfor studying the transcriptome. One of many aspects of transcriptomics that are of interest to researchers is gene expression estimation. With rapid development in RNA-Seq, there are numerous tools available to estimate gene expression, each producing different results. However, we do not know which of these tools...
In this paper, we present the fabrication and testing of a monolithic polymer Joule-Thomson (J-T) micro cryogenic cooler (MCC) cold stage. The MCC cold stages are fabricated monolithically on a wafer all of polyimide. The fabrication is based on surface micro-machining technology using electroplated copper as the sacrificial layers and polyimide as the structural material. One of the techniques enabling...
In recent years, electrical discharge plasmas have been used as an effective method for treating water containing environmental pollutants. Some researchers have reported that species with high oxidation potential such as OH radical, O radical, and O3 are produced by pulsed discharge plasmas generated in or at water surface. Effective treatment of polluted water can be expected by these species. Previously,...
This paper introduces the first MEMS-based purge-and-trap (P&T) system and reports a new microfabricated column for onsite monitoring of water organic compounds (WOCs). The micro purge extractor (μPE) consists of etched cavity inside 2 cm × 3 cm chip and is used to purge WOCs from aqueous sample. The extracted WOCs are collected onto our previously reported micropreconcentrator (μPC) and subsequently...
Speckle contrast < 3.5% was achieved by means of (i) wavelength-diversity using spectrally-broad nonlinear photonic green lasers over the 520–545nm range and (ii) polarization- and phase-diversity using birefringent nano-photonic devices.
Pulsed discharge plasmas, a type of non-thermal plasma, have received much attention as an abundant radical source. Pulsed discharge is mainly divided into two phases: A streamer discharge, which has a streamer head with very high electron energy; and a glow-like discharge, which forms between electrodes uniformly. Many types of radical are produced by the streamer head, while the glow-like discharge...
In recent years, electrical discharge plasmas have been used as effective methods for treating water having environmental pollutants. Some researchers reported that the species which have high oxidation potential, such as OH radical, O radical, O3 and etc., are produced by pulsed discharge plasmas generated in water or water surface. Therefore, the effective treatment of the polluted water can be...
Pulsed discharge plasmas which are one of the non-thermal plasma have received much attention as an abundant radical source. Pulsed discharge is mainly divided into two phases. One is streamer discharge which has streamer head with very high electron energy, and the other is glow-like discharge which discharge between electrodes uniformly [1]. Many types of radical are produced by streamer head. On...
We present an agent-based model of head and neck cancer cell population dynamics that investigates the effect of cooperative interactions between individual cancer cells during the course of cytotoxic drug treatment. A model of cooperative behavior based on the Lotka-Volterra competition equations is combined with a model of drug resistance and response. Predictions regarding the individual and combination...
Cloud computing services offer highly reliable, scalable and efficient solutions with a large pool of easily accessible, virtualized resources. They are becoming an increasingly prevalent delivery model. We have developed a cloud-based image analysis toolbox to provide a wide user base with easy access to the software tools we have developed over the last decade. The toolbox is provided as a service...
Mutations in EGFR kinase domain can cause non-small-cell lung cancer, which is one of the most lethal diseases in the world. However, current therapy is limited by the drug resistance effect in different EGFR mutants. There is an urgent demand for developing computational methods to predict drug resisted mutations. In this study, we use quantum mechanics and molecular mechanics models to generate...
The effect of early failure model on upstream EM reliability and its improvements are investigated in a 45nm CMOS process. The effective process optimizations of tapered via profile by organic under layer (ODL) over etch (OE) at chamfer area and enlarged trench CD have been analyzed and discussed. Recent observations shown tapered via profile at chamfer area can get much larger angle for barrier seed...
This paper presents the study of silicon wafer modification by two-beam laser interference. In the work, two-beam laser interference was used to pattern single crystal silicon wafers for the fabrication of gratings, and different laser faiences and pulses were applied to the process in the air. The results were obtained from single laser pulse exposures with the laser fiuences of 637mJ/cm2, 780mJ/cm...
We present an LED light source for use with standard clinical endoscopes to enable visualization of tissues labeled with quantum dots (QDs). QD-assisted endoscopy may improve the outcome of surgical endoscopic procedures by identifying specific tissue types. QDs offer several advantages over current fluorescent stains due to their high target selectivity, long-lasting fluorescence, large excitation...
We design and demonstrate electrically controlled optical trapping of individual microparticles and manipulation of biomolecules with nm-scale precision for high throughput applications. This has been realized by integration of photonics, fluidics, and electronics, on-chip.
Accurate quantification of gene or isoform expression with RNA-Seq depends on complete knowledge of the transcriptome. Because a complete genomic annotation does not yet exist, novel isoform discovery is an important component of the RNA-Seq quantification process. Thus, a typical RNA-Seq pipeline includes a transcriptome mapping step to quantify known genes and isoforms, and a reference genome mapping...
Next-generation sequencing (NGS) has brought human genomie research to an unprecedented era. RNA-Seq is a branch of NGS that can be used to quantify gene expression and depends on accurate annotation of the human genome (i.e., the definition of genes and all of their variants or isoforms). Multiple annotations of the human genome exist with varying complexity. However, it is not clear how the choice...
Power transformers are considered to be one of the most critical components of a power system. Due to ageing the majority of transformer populations are at or approaching their anticipated design lives, causing growing concerns over possible consequential impacts to system reliability. It is essential for utilities to maintain high levels of system reliability and ensure the continued cost-effectiveness...
Under normal circumstances, power transformers are designed to predominantly operate within the linear portion of the transformer core magnetization curve. The basic goal of this design is to retain a reasonable amount of linearity and to stay below flux density values that would incur excessive losses. In recent years, however, we are facing more challenges of saturation, such as the half-cycle saturation...
Oil tests are crucial for condition assessment of transformers. Moisture, acidity, breakdown voltage, dissolved gas analysis and furans analysis are common oil tests carried out by utilities. IEC 60422 and IEC 60599 have specified some limit values for detecting any abnormalities based on oil tests. However, these limit values might not be suitable for all transformers at different ages or under different...
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