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Following a previous study reporting that BRK1 is upregulated in non-small cell lung cancer (NSCLC), the present study sought to clarify the role of specificity protein 1 (Sp1) in the transcriptional regulation of the BRK1 gene. Therefore, a construct, named F8, consisting of the −1341 to −1nt sequence upstream of the start codon of the BRK1 gene inserted into pGL4.26 was made. A series of truncated...
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