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In article number 1800573 by Xin Lou and co‐workers, an αvβ3‐specific Fe3O4‐RGD nanoprobe is prepared for in vivo magnetic resonance imaging of the collaterals after cerebral ischemia, and shows the binding specificity to the cerebral collaterals. The direct observation of cerebral collaterals is enabled in a quasi‐real time fashion, and further studies are also performed to show the collateral dynamics...
Ischemic stroke is one of the major leading causes for long‐term disability and mortality. Collateral vessels provide an alternative pathway to protect the brain against ischemic injury after arterial occlusion. Aiming at visualizing the collaterals occurring during acute ischemic stroke, an integrin αvβ3‐specific Fe3O4–Arg‐Gly‐Asp (RGD) nanoprobe is prepared for magnetic resonance imaging (MRI) of...
A tumor microenvironment responsive nanoprobe is developed for enhanced tumor imaging through in situ crosslinking of the Fe3O4 nanoparticles modified with a responsive peptide sequence in which a tumor‐specific Arg‐Gly‐Asp peptide for tumor targeting and a self‐peptide as a “mark of self” are linked through a disulfide bond. Positioning the self‐peptide at the outmost layer is aimed at delaying the...
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