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The MRL/Mp mice bearing a lymphoproliferative gene,lpr(MRL/Mp-lpr/lpr), provide an appropriate model for the study of autoimmune mechanisms leading to the destruction of salivary and lacrimal gland tissue in Sjögren's syndrome. By 7–8 weeks of age, progressive focal inflammatory cell infiltrates are observed in salivary glands. We examined the possibility of transferring this disorder into syngeneic,...
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