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MicroRNAs (miRNAs) are small noncoding RNAs which regulate gene expression. In this research, we used the Multiz alignments data of 44 Vertebrates to retrieve syntenic homolog sequences. And we identified 37 members of miR-1302 family among 71 potential homolog sequences. Then we analyzed the 37 homologs of hsa-mir-1302s by RepeatMasker and found all of these sequences are derived from MER53 elements...
Due to involvement in changing of chromatin structure, histone modifications are very important in regulation for gene expression. Some attempts have been done to resolve the relationship among histone modifications and gene expression. In this study, four types of Bayeasian network methods, Maximum weight spanning tree (MWST), K2, Markov Chain Monte Carlo (MCMC) and greedy-search(GS), are used to...
Many high-throughput DNA sequencing methods provide very short reads, typically of a few tens of base pairs. New algorithms and softwares are needed to analysis those short reads effectively. There are some software tools for aligning short reads to a reference genome. Here we introduce a new method, Umap, to align theses short reads faster and more exact. Applying Umap to simulated very short reads...
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