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The Ca2+ modulation in the dorsal raphe nucleus (DRN) plays an important role in sleep–wake regulation. Calmodulin‐dependent kinase II (CaMKII) is an important signal‐transducing molecule that is activated by Ca2+. This study investigated the effects of intracellular Ca2+/CaMKII signaling in the DRN on sleep–wake states in rats. Maximum and minimum CaMKII phosphorylation was detected at Zeitgeber...
Serotonergic neurons in the dorsal raphe nucleus (DRN) are involved in the control of sleep-wake states. Our previous studies have indicated that calcium (Ca2+) modulation in the DRN plays an important role in rapid-eye-movement sleep (REMS) and non-REMS (NREMS) regulation during pentobarbital hypnosis. The present study investigated the effects of Ca2+ in the DRN on sleep-wake regulation and the...
Studies suggest a tight relationship between protein kinase C (PKC) and circadian clock. However, the role of PKC in sleep–wake regulation remains unclear. The present study was conducted to investigate the role of PKC signaling in sleep–wake regulation in the rat. Our results showed that the phosphorylation level of PKC in dorsal raphe nucleus (DRN) was decreased after 6h sleep deprivation, while...
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