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Regulation of cellular Ca 2+ cycling is central to myocardial contractile function. Loss of Ca 2+ regulation is associated with cardiac dysfunction and pathology. Estrogen has been shown to modify contractile function and to confer cardioprotection. Therefore, we investigated the effect of estrogen on expression of rat heart myocardial Ca 2+ -handling proteins and beta-adrenergic...
Human studies reveal sex differences in myocardial function as well as in the incidence and manifestation of heart disease. Myocellular Ca 2+ cycling regulates normal contractile function; whereas cardiac dysfunction in heart failure has been associated with alterations in Ca 2+ -handling proteins. Beta-adrenergic receptor (β-AR) signaling regulates activity of several Ca 2+ ...
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