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In the present study, we characterized biologic and electrophysiologic consequences of A422T mutation in HERG K + channel and the role of pharmacologic or molecular chaperons by employing a heterogeneous expression system in HEK 293 cells. It was found that A422T mutation led to a marked decrease in whole-cell recording currents, and that a complexly glycosylated form protein band at 155kDa...
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