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In order to investigate the toxic effect of intermittent high glucose (IHG) and sustained high glucose (SHG) on rat pancreatic beta cell functions and the potential involved mechanisms, isolated rat islets and INS-1 beta cells were exposed to SHG (25mmol/l) or IHG (11.1 and 25mmol/l glucose alternating every 12h) for 72h. The results showed that IHG induced a more significant impairment of insulin...
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